Finite Element Modeling of Vasoreactivity Using COMSOL Multiphysics® Software
Localized calcium events in the endothelial cells (EC) can modulate smooth muscle cell (SMC) calcium (Ca2+) and membrane potential dynamics through release of endothelium derived hyperpolarizing and relaxing factors. Ca2+ levels in the smooth muscle cell (SMC) determine its contractile state.The underlying complex mechanism regulating the SMC Ca2+ levels and ultimately vessel tone remains poorly understood. We developed coupled EC-SMC continuum models to describe function at macro-scale level by integrating mechanisms at the subcellular/ molecular level. Cellular models were coupled through diffusion of ions and second messengers. The models allows introduction of spatial distribution of cellular components and microdomains. The model will provide quantification and better understanding of localized events in the EC and its modulation of the vessel tone.
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